ea0094p319 | Adrenal and Cardiovascular | SFEBES2023
Jarvis Sheba
, Servin-Recio Renee
, Varela-Carver Anabel
, Reddy Velma Ganga
, Thatcher Gregory
, Bevan Charlotte
Adrenocortical carcinoma (ACC) is a rare tumour with a poor prognosis. There are a lack of successful targeted therapies and an urgent need to explore novel therapeutic avenues for ACC 1. In other cancer types, there has been some success in exploiting lipid metabolism. One example is manipulating intracellular cholesterol levels to starve cancer cells. 2 Another possibility is targeting the ligand-dependent nuclear receptors Liver-X receptors (LXRab), wh...